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HelixEVO LabsGHK-Cu40 mgLOT ________For research use only. Not for human or veterinary use.STORE 2–8 °CHelixEVO LabsGHK-Cu40 mgLOT ________For research use only.Not for human or veterinary use.STORE 2–8 °C
Research peptide

GHK-Cu

GHK-Cu

Specification
Total quantity
40 mg
Pack
Sealed glass vial(s); vial count confirmed before release
Form
Lyophilised powder
Stated purity
Reported per lot on the certificate of analysis
Appearance
Lyophilised powder in a sealed glass vial; the literature records dark purple-blue crystals for the complex.
Storage
2–8 °C, sealed, protected from light
Shipping
Dispatched from the United Kingdom under cold chain, Monday to Wednesday only, so that no consignment is held in transit over a weekend. Insulated packaging with gel coolant, on a tracked service.
SKU
HX-GHKC-40
AvailabilityOut of stock

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For laboratory research use only. Not for human or veterinary consumption.

Analytical data

Latest released lotNo released lot yet

Analytical data appear here as soon as the first lot is released. Every released lot carries a certificate with HPLC purity and MS identity per compound.

Method

Purity by reversed-phase HPLC with UV detection; identity by electrospray mass spectrometry against the calculated monoisotopic or average mass. Endotoxin where stated. The certificate names the laboratory and the method for every result.

How to read a certificate →

Identity

Identity · GHK-Cuverified 2026-09-21
In this product
40 mg
Synonyms
Copper tripeptide-1, Prezatide copper, GHK copper, GHK complex with copper, Copper, (N2-(N-glycyl-L-histidyl)-L-lysinato(2-))-, Copper, (glycyl-kappaN-L-histidyl-kappaN,kappaN3-L-lysinato(2-))-, L-Lysine, N2-(N-glycyl-L-histidyl)-, copper complex, CG-copper peptide, Glycyl-L-histidyl-L-lysine-Cu2+
CAS
89030-95-5· PubChem (NCBI), FDA / NCATS Global Substance Registration System, Cosmetic Ingredient Review
UNII
6BJQ43T1I9· FDA / NCATS Global Substance Registration System, PubChem (NCBI)
PubChem CID
71587328
Formula
C14H22N6O4.Cu· FDA / NCATS Global Substance Registration System, PubChem (NCBI)
Mol. weight
401.91 g/mol· FDA / NCATS Global Substance Registration System, PubChem (NCBI)
Class
Copper(II) complex of a naturally occurring tripeptide (first isolated from human plasma); used as a cosmetic skin-conditioning ingredient
Targets
None identified in retrieved sources
Modifications
Unmodified linear tripeptide with free N-terminus and free C-terminal carboxylate (H-Gly-His-Lys-OH), complexed 1:1 with copper(II). In solution the complex is monomeric with three nitrogen donors (glycine amino N, deprotonated amide N, histidine imidazole N); in the solid state it is dimeric, with the fourth equatorial site occupied by a labile carboxylate oxygen. The lysine side-chain amine takes part in coordination only at alkaline pH.
Sequence (one-letter) · 1 residues
  1. GHK

Research overview

GHK-Cu is the 1:1 copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine, and it is a separate registry substance from the free tripeptide. The complex is registered as prezatide copper, CAS 89030-95-5, UNII 6BJQ43T1I9, with the INCI name Copper Tripeptide-1; the free peptide is registered as prezatide, CAS 49557-75-7, C14H24N6O4, 340.38 g/mol 12. Two molecular weights are published for the complex: 401.91 g/mol for the neutral representation held by the substance registry and by PubChem CID 10111685, and 402.92 g/mol for the cationic representation on CID 71587328, the record that carries the CAS number and the UNII. The difference is one proton in how the same complex is drawn, not two materials 34. Structural work describes a complex that is monomeric in solution, with three nitrogen donors and a labile fourth equatorial site, and reports a conditional dissociation constant at pH 7.4 of 7.0 plus or minus 1.0 times 10 to the power minus 14 M 56. The substance has an INCI name, a CosIng entry giving the function skin conditioning, and a 2014 Cosmetic Ingredient Review assessment 78. The published research literature is in cell culture and animal models; it is set out with evidence levels in the knowledge-base monograph. This material is supplied for laboratory research only.

  1. 1.PREZATIDE COPPER, UNII 6BJQ43T1I9 (substance record, JSON). FDA / NCATS Global Substance Registration System (2026). source
  2. 2.PREZATIDE, UNII 39TG2H631E (substance record, JSON). FDA / NCATS Global Substance Registration System (2026). source
  3. 3.Copper glycyl-histidyl-lysinate, neutral record (CID 10111685). PubChem (NCBI) (2026). source
  4. 4.Prezatide copper (CID 71587328). PubChem (NCBI) (2026). source
  5. 5.Hureau C, Eury H, Guillot R, Bijani C, Sayen S, Solari PL, Guillon E, Faller P, Dorlet P. X-ray and solution structures of Cu(II) GHK and Cu(II) DAHK complexes: influence on their redox properties. Chemistry - A European Journal (2011). doi:10.1002/chem.201100751
  6. 6.Trapaidze A, Hureau C, Bal W, Winterhalter M, Faller P. Thermodynamic study of Cu2+ binding to the DAHK and GHK peptides by isothermal titration calorimetry (ITC) with the weaker competitor glycine. Journal of Biological Inorganic Chemistry (2012). doi:10.1007/s00775-011-0824-5
  7. 7.CosIng ingredient record 55687: COPPER TRIPEPTIDE-1. European Commission (2026). source
  8. 8.Johnson W Jr; Heldreth B; CIR Expert Panel. Safety Assessment of Tripeptide-1, Hexapeptide-12, their Metal Salts and Fatty Acyl Derivatives, and Palmitoyl Tetrapeptide-7 as Used in Cosmetics. Final Report, 30 June 2014. Cosmetic Ingredient Review (2014). source
GHK-Cu monograph

Regulatory status

Regulatory status · GHK-CuCosmetic and biochemical research ingredient

This material is supplied as a research chemical. It is not a cosmetic product, has not been assessed for any finished-product use, and is supplied for laboratory research only.

The rows below record the ingredient status found in each jurisdiction on the date checked.

United Kingdom
No entry containing the word 'tripeptide' was found in the legislation.gov.uk text of assimilated Regulation (EC) No 1223/2009 on 2026-09-21; cosmetic products on the GB market are governed by that Regulation and the Cosmetic Products Enforcement Regulations 2013.Checked 2026-09-21 · legislation.gov.uk (The National Archives)
European Union
COPPER TRIPEPTIDE-1 is listed in the European Commission CosIng database (reference 55687) with the function skin conditioning, with no CAS or EC number, no Cosmetics Regulation provision, no other restriction and no SCCS opinion shown.Checked 2026-09-21 · European Commission
United States
On FDA's 503A nominated bulk drug substances list updated 14 May 2026, 'GHK-Cu (except for injectable routes of administration)' appears in Category 1 (under evaluation); GHK-Cu is not on the 503A bulks list itself, and no Drugs@FDA application was found for prezatide copper on 2026-09-21.Checked 2026-09-21 · US Food and Drug Administration
WADA Prohibited List
GHK, GHK-Cu, copper tripeptide and prezatide are not named anywhere in the 2026 Prohibited List (in force since 1 January 2026) as published on WADA's web edition.Checked 2026-09-21 · World Anti-Doping Agency
Handling and safety

Handle as a research chemical of unknown hazard in a laboratory setting with appropriate protective equipment. Keep sealed at 2–8 °C and protected from light. Safety data sheet: available on request until the SDS is published here.

Shipping

Dispatched in insulated cold-chain packaging with a coolant, Monday to Wednesday, to laboratory and business addresses within the United Kingdom. Destination rules are on the shipping policy.

Questions

Which substance does the name GHK-Cu refer to here?
The copper complex, not the free tripeptide. The identity used throughout the knowledge base is CAS 89030-95-5, UNII 6BJQ43T1I9 and PubChem CID 71587328, INCI name Copper Tripeptide-1 [gsrs-prezatide-copper][pubchem-71587328]. The free tripeptide glycyl-L-histidyl-L-lysine is a separate record, CAS 49557-75-7, UNII 39TG2H631E, INCI name Tripeptide-1 [gsrs-prezatide][pubchem-73587]. PubChem lists GHK-Cu as a depositor synonym on the free-peptide record as well, so a name alone does not settle which substance a document describes [pubchem-73587].
Why do two different molecular weights appear for this complex?
Because two registry records draw the complex in different protonation states. The substance registry and PubChem CID 10111685 give C14H22N6O4.Cu at 401.91 g/mol for a neutral species, while PubChem CID 71587328, which carries the CAS number and the UNII, gives C14H23CuN6O4+ at 402.92 g/mol for a singly charged cation [pubchem-10111685][pubchem-71587328]. The research dossier records both rather than choosing one. Neither figure covers an acetate or trifluoroacetate form of the complex [pubchem-71587328].
How is purity established, and what does the literature say about it?
Purity is reported as reversed-phase HPLC main-peak content with identity confirmed by mass spectrometry. No pharmacopoeial monograph for this substance was retrieved in the research behind this listing, and the one published cosmetic HPLC method omits flow rate, gradient and validation data [dymek-2023-pharmaceutics]. The Cosmetic Ingredient Review report states that commercial glycyl-L-histidyl-L-lysine is approximately 95% pure, and its summary attributes the same figure to the complex, an inconsistency recorded in the dossier [cir-2014-tripeptide1].
What does the certificate of analysis cover?
Each lot is released against its own certificate of analysis, which records the identity and purity results, the methods used and the lot number, so that a vial can be matched to its record. Because two molecular weights are in circulation for this complex, the certificate should be read together with the identity data above.
What storage condition is listed for this material?
The listed storage condition is 2 to 8 °C, and the condition under which a lot was held is recorded on its certificate of analysis. No allowed source retrieved for the research dossier reports storage conditions or a shelf life for the lyophilised complex, so no literature figure is quoted here [cir-2014-tripeptide1].
What does a pack contain?
A pack contains a total of 40 mg of GHK-Cu as lyophilised powder in sealed glass vials. Until the split of that total across vials has been confirmed for a lot, the listing states the total quantity only.